Geologic deposits susceptible to ground motion amplification under seismic loading in the New Madrid Seismic Zone are delineated using multiple data sources including in situ measurements, geologic maps, and remote-sensing imagery. Soils are classified on the basis of the recommendations from the National Earthquake Hazards Reduction Program, which recommends a classification based on the average shear wave velocity of the geologic material in the upper 30 m. Measurements of shear wave velocity were obtained from Central United States Earthquake Consortium state geologists, the U.S. Geological Survey, and several researchers. However, since this is a predominantly rural area, limited field test data are available. Therefore, several other data sources are introduced including geologic maps and remote-sensing imagery to extrapolate dynamic properties in areas lacking extensive field measurements. Each data source was incorporated into a geographic information system for subsequent analysis. Bridges susceptible to failure from amplification of seismic waves and located on key transportation routes are identified for subsequent risk assessment or seismic retrofitting since the performance of these structures affects disaster planning and rescue efforts and may have severe consequences for the national economy.