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An intersubstance approach to drug-concentration-drug effect correlation via metaanalytic data of experimental studies Berghaus, G ; Grass, H ; Sticht, G

By: Berghaus, GContributor(s): Grass, H | Sticht, GPublication details: Alcohol, drugs and traffic safety, 2000; T2000, Stockholm, May 22-26, 2000. Paper, Description: 4 sSubject(s): Sweden | Conference | Drugs | Performance | | Stochastic | | 842Bibl.nr: VTI P4030:15Location: Abstract: Based on a metaanalytical analysis of experimental studies combined with pharmacokinetic data we tried to correlate the time of worst human performance and the time of highest serum-concentration after oral application of several drugs. Critically discussed we can postulate as a first result that the dosage does not influence the time of highest concentration but the time of worst performance, and that for substances with short resorption times the maximum of performance decrements is situated after the maximum of concentration and vice versa.
Item type: Reports, conferences, monographs
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Based on a metaanalytical analysis of experimental studies combined with pharmacokinetic data we tried to correlate the time of worst human performance and the time of highest serum-concentration after oral application of several drugs. Critically discussed we can postulate as a first result that the dosage does not influence the time of highest concentration but the time of worst performance, and that for substances with short resorption times the maximum of performance decrements is situated after the maximum of concentration and vice versa.

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