Arterial hypertension (AH) is one of the most spread diseases in our country. Its rates in Russia are very high indeed, and the mean percentage in males reaches 18.6 per cent, in females - 19.3 per cent. Meanwhile, the population is rather poorly informed about AH: more than half of the subjects are unaware of their disease, in those aware, only 17 per cent are embraced with treatment being effective just in 8 per cent of the total. The AH spread index among vehicle drivers is now having an increasing trend, and for the recent 14 years has had a 2.9 per cent rise. There is a number of working factors involved in driving performance: chronical nerve-emotional strain, hypodynamics, hypokenesis in combination with noise, vibration, infrasounds, toxic substances that may be the reasons for the disfunctions of the cardio-vascular system, and AH, as well. Heavy and malignant forms of AH are a contraindication to drive. A hypotensive therapy in VD with AH has its own peculiarities. Within this study, it was first attempted to break down the qualities of athenolol and ramipril on persons having a mild and moderate AH; the hypotensive therapy efficacy was assessed by haemodynamic indices, while the treatment safety was determined by registrations of side effects and the impact of drugs on PRF.