If the prevalence of drug driving clearly reaches the awareness threshold of the policy makers and public of a given country, will they then give the problem a higher priority? Will the relevant infrastructures in the areas of enforcement, forensic toxicology, prosecution, the courts, and prevention be available and adequate to meet the new pressures for expansion? In attempting to address the last question, specific additional tasks of the Council of Europe Pompidou Group s project on Drugs in Road Traffic consisted of surveying and assessing the status of the relevant existing infrastructures, regulations, procedures, and programs in the areas of enforcement, measurement, prosecution, and prevention within each of the 17 participating countries. The present paper reviews and summarises the cross-national results of these specific tasks and the challenges uncovered among the 17 participating member countries.