Studies on work zone crashes typically examine a combination of injury, fatal, and property damage crashes to identify factors that contribute to unsafe conditions within work zones. Few studies focus on fatal crashes within work zones, although a clear understanding of the driver, roadway, and work zone conditions associated with fatal crashes will facilitate the development of strategies aimed at improving safety and reducing fatal as well as nonfatal crashes. The Georgia Department of Transportation recently performed a study to identify the manner of collision, location, and construction activity associated with fatal crashes in work zones. This study is expanded further to examine the difference between fatal crash activity within work zones compared with fatal crashes in non-work-zone locations. Using data from three work zone locations in Georgia, fatal crash activity within work zones also was compared with nonfatal crashes within work zones. Finally, fatal crash activity was examined to determine the influence of the work zone activity on the frequency of fatal crashes. The overall findings of the study indicate that the work zone influences the manner of collision, light conditions, truck involvement, and roadway functional classification under which fatal crashes occur. The study also indicates that fatal crashes in work zones are more likely to involve another vehicle than non-work-zone fatal crashes, and fatal crashes in work zones are less influenced by horizontal and vertical alignment than are non-work-zone crashes.