A comprehensive constitutive model for asphalt concrete was calibrated that included viscoelasticity, viscoplasticity, and irreversible microstructural damage in unconfined compression. Three different types of laboratory tests were designed and performed to calibrate each of these response components. Small-strain dynamic modulus tests were used to calibrate the undamaged linear viscoelastic properties. Cyclic creep and recovery tests to failure were performed to calibrate the viscoplastic properties. Constant-rate-of-strain tests to failure were used to calibrate the damage behavior. These tests were performed at a wide range of temperatures, loading rates, and stress levels. Upon calibration of each individual response, the model was validated by predicting the results of other constant-rate-of-strain tests at temperatures and strain rates different from those used in the calibrations. The predictions for these different conditions indicate that the comprehensive model can realistically simulate a wide range of asphalt concrete behavior.