In Inner Mongolia, for its complex landform and various climate type, it has many kinds of road diseases with a wide range and great intensity. Ice-snow road is one of the main diseases that lead to unsafe driving and transportation suspension. It not only costs much to resume the transportation, but also seriously affects the operation benefits and leads to several million Yuan's loss every year. So it is of great importance to carry out a research on prevention and treatment of the road diseases. Road and meteorology are two closely correlative borderline subjects. Ice-snow roads combine the two meteorological factors (wind and snow) together. Utilizing fifty years meteorological data, by means of the methods of mathematical statistics, we analyze the distribution of ice-snow disaster with the change of year, month and space-time, the formation reasons of ice-snow road are also put forward. The measures to protect ice-snow road from damage are given below: (1) nipping in the bud, from reconnaissance design work; (2) adjusting measures according to local condition, improve the facilities of preventing snow; (3) doing precautions work well, avoiding snow accumulating on the road surface; (4) using biology prevention, improve highway ecological environment; and (5) synthetic treatment and establishing a perfect drainage system.