This paper presents a simulation-based system for Ocean City, Maryland, evacuation during hurricanes. The proposed model features integration of optimization and simulation that allows potential users to revise the optimized plan for both planning and real-time operations. Since it is difficult to capture all network operational constraints and driver responses fully with mathematical formulations, six evacuation plans for Ocean City were investigated. Each was optimized initially with the optimization module and then revised on the basis of the results of simulation evaluation. To address potential incidents during the evacuation, the study presents a real-time operation plan with a developed system that allows the responsible operators to concurrently evaluate all candidate responsive strategies and to track the performance over time of the implemented strategy.