Globally, the WHO (2009) estimates that approximately 1.2 million people die annually from road traffic crashes especially among vulnerable road users (i.e. children, pedestrians, cyclists and the elderly). Human-related factors such as culture, risk perception, attitudes and risktaking behaviour contribute substantially to this safety problem. Surveys on risk and safety are, however, rare especially in Sub-Saharan Africa. Thus, this present study aims to analyse some cultural aspects of risk with respect to road safety by comparing a sample population in Ghana and Norway respectively. Judgment of traffic injury risks, attitudes and behaviours towards road safety, and the role of culture between road users are also explored. An additional objective is a discussion of the suitability of application of various road safety strategies for developing countries. The choice of these two countries are informed by the fact that they differ largely on levels of infrastructure development to minimise exposure of vulnerable road users to traffic injuries; degree of motorisation and consequent high incidence of traffic accidents as well as their cultural values. The analyses are carried out from a similar questionnaire survey data used by generated through stratified sampling of respondents (N = 299) in the Ghanaian cities of Accra and Cape Coast, as well as a representative sample of the Norwegian public above 16 years (N = 247). Stratified analyses of mean (sum) scores for risk perception, attitudes and behaviour and in addition regression models were performed for explaining variance for the two countries. The results show that Ghanaian vulnerable road users report higher injury risk perceptions than their Norwegian counterparts. Ghanaians also express more favourable safety attitudes and safety behaviour, except for drinking and driving. These finding may be interpreted in relation to the differences in the traffic system and the overall risk environment in the two countries. Age, gender and education are generally insignificant predictors for attitudes and behaviour both in Ghana and Norway, except partly for gender in the latter. Certain cultural traits, such as sounds, honking of horns and other movements in traffic are more important than the influence of traffic signs on attitudes in Ghana. However, most elements of culture are embedded in the systematic country differences. More holistic strategies at the micro, meso and macro levels seem to be most appropriate for reducing risk culture, risk attitudes and contribute to safety-mindedness in behaviour. These include: individual and collective behavioural improvements through wellpublicised and sustained road safety education emphasising personal responsibility in traffic, strict enforcement of legislations on the use of seatbelts, child restraints, and crash helmets as well as random breath-tests to check drink driving and the construction of speed calming facilities in risk-prone areas will positively affect safety behaviour and improve road safety.