This paper provides a study of existing cargo securing regulations applied for road transport by different national regulations, standards and guidelines. Since no universal standard has been globally accepted yet, differences in cargo securing requirements may lead to complexity, especially when multimodal transports are to be performed. Such barriers may potentially affect the development of free trade. A case study has been executed in order to demonstrate the effect of different regulations on cargo securing for road transport. In the paper a proposal is presented on how to harmonization can be achieved. The results are supposed to attract a wide range of stakeholders, aiming to define a common vision and legislative structure on forthcoming regulations in the cargo securing field. The result will also be used as an input to the present work in the UNECE expert group working with the revision of the IMO/ILO/UNECE Guidelines for Packing of Cargo Transport Units to prepare an international Code of Practice for Packing of Cargo Transport Units.