The automotive industry is shifting its focus on energy efficient driving to tackle rising environmental issues. In this direction, as exhaust particle emissions continuously decrease, the attention is turned on non-exhaust traffic related sources in ground vehicles, such as the interaction between tyre and roads and the tyre wear. Given that the tyres are costly for the vehicle owner and wear creates large waste of old tyres, the modelling and the minimisation of tyre wear have been of great interest recently. The tyre wear is mainly caused by inner (tyre structure and shape) and external (suspension configuration, speed, road surface, etc.) factors. So, this work presents a sensitivity analysis of both inner and external factors, and then explores the optimisation of tyre and suspension parameters for minimising tyre wear and enhancing comfort. More specifically, initially the inner factors are investigated regarding their impact on tyre wear, while external factors, i.e., vehicle loading, velocity and road type, which can be different daily regarding the purpose of the ride, are studied regarding both comfort and tyre wear outlining the conflicting relation between these two objectives. Finally, informed by the results, the optimum tyre and suspension design for a passenger vehicle are sought to both minimise tyre wear, enhance comfort and improve vehicle stability in normal loading conditions while the vehicle drives in a city road (Road Class A) with normal speed.