The objective of this feasibility study is to evaluate if it is feasible to operate large, unmanned cargo ships with human support from a ROC, i.e., constrained autonomy, that can operate in international waters. In this study, the term cargo ship is used to include deep sea break-bulk and short sea container ships. A prerequisite for the study is that the ship is operating in international waters and can visit any port. Additionally, it is assumed that the unmanned cargo ship is a new build and without superstructure, and Norwegian regulations are considered when discussing national regulations. The feasibility is evaluated based on technical, regulatory, and commercial assessments. Moreover, to evaluate the feasibility of an unmanned cargo ship, the voyage is divided into different operational phases: At port, near port, coastal and deep sea. Next, the functions performed on board a cargo ship today is divided into different crew tasks: Navigation and control, propulsion system, communication, cargo handling, and mooring. Lastly, the feasibility of performing each task autonomously is evaluated for each operational phase. The evaluation is based on input from the project partners and other available sources.